Multomic analysis reveals the potential of LAG3 as a prognostic and immune biomarker and its validation in osteosarcoma



Summary

A multomic analysis of osteosarcoma (OS) reveals LAG3’s potential as a significant prognostic and immune biomarker. By integrating genomic, transcriptomic, and proteomic data, researchers identified a strong correlation between LAG3 expression and poor patient survival in OS. Further investigation highlighted LAG3’s role in modulating the tumor microenvironment and influencing immune cell activity, suggesting its involvement in immune evasion. These findings were validated in independent OS cohorts, solidifying LAG3 as a promising target for immunotherapy and a valuable tool for predicting patient outcomes in this aggressive bone cancer.

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