CAR-T cell therapy for cancer: current challenges and future directions Summary CAR-T cell therapy has revolutionized cancer treatment, particularly for hematologic malignancies, by engineering a patient’s immune cells to target and destroy cancer cells. Read More
The Korea Research Institute of Standards and Science has successfully developed a nanomaterial capable of simultaneously performing cancer diagnosis, treatment, and immune response induction. Compared to conventional nanomaterials that only perform one function, this new Read More
Evolutionary regulation of human Fas ligand (CD95L) by plasmin in solid cancer immunotherapy Summary Human Fas ligand (CD95L) is a key player in immune cell-mediated killing of cancer cells. However, cancer cells can Read More
Different tumour-resident memory T-cell subsets regulate responses to anti-PD-1 and anti-CTLA-4 cancer immunotherapies Summary Tumour-resident memory T cells (Trm) are critical for effective cancer immunotherapy, but their heterogeneity and specific roles remain unclear. Research reveals Read More
Sintilimab and anlotinib with gemcitabine plus cisplatin in advanced biliary tract cancer: SAGC a randomized phase 2 trial Summary The SAGC trial, a randomized phase 2 study, investigated the efficacy of sintilimab (a PD-1 inhibitor) and anlotinib (Read More
PPP2R1A mutations portend improved survival after cancer immunotherapy Summary Mutations in the PPP2R1A gene, encoding a scaffolding subunit of the PP2A phosphatase complex, are linked to better survival outcomes in Read More
Immune-checkpoint targeting drug conjugates: a novel class of promising therapeutic agents for cancer treatment Summary Immune-checkpoint targeting drug conjugates (ICT-DCs) represent a promising new strategy in cancer treatment. These conjugates combine the precision of immune Read More
A lentiviral vector targeting a KRAS neoepitope for cancer immunotherapy Summary Researchers have developed a lentiviral vector to deliver a neoepitope derived from a common KRAS mutation (G12D) directly to antigen-presenting cells (APCs). This Read More
How can cannabis be used to help chemotherapy patients? This is what a recent study published in Pharmacology & Therapeutics hopes to address as a team Summary A recent Pharmacology & Therapeutics study explores how cannabis Read More
Caffeine enhances antitumor T-cell activity by suppressing kynurenine pathway in colorectal cancer Summary A new study reveals that caffeine boosts the immune system’s ability to fight colorectal cancer by targeting the kynurenine pathway. Caffeine Read More
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