Leukocyte Recruitment Leukocyte recruitment is a critical process in the immune system’s response to infection and injury. It involves the movement of white blood cells (leukocytes) from the bloodstream to sites of inflammation, infection, Read More
Adhesion Molecules in Cellular Migration, Inflammation and Disease Adhesion molecules are integral membrane proteins that play critical roles in cellular interactions and communication. They are essential in facilitating cellular migration, particularly in the context of Read More
Chemokines and Chemoattractants Chemokines and chemoattractants are signaling molecules that play a crucial role in the immune system by directing the movement of cells, particularly immune cells, towards sites of infection, injury, or inflammation. These Read More
Tolerance and Autoimmunity Tolerance and autoimmunity are foundational concepts in immunology that describe how the immune system distinguishes between the body’s own cells and foreign invaders like pathogens. Properly functioning immune tolerance prevents the Read More
Immunopathogenic Mechanisms/Immunogenetics of Autoimmunity Autoimmunity refers to a group of disorders where the immune system mistakenly targets and attacks the body’s own tissues. This aberrant immune response stems from a complex interplay of Read More
Structure/Function Studies of Antigen Processing and Presentation The intricate process of antigen processing and presentation is fundamental to the immune response, enabling the recognition of a vast array of pathogens by T cells. This Read More
Antigen Presenting Cells Antigen-presenting cells (APCs) play a crucial role in the immune system, bridging innate and adaptive immunity. They are responsible for capturing, processing, and presenting antigens to T cells, thus enabling the body Read More
Intracellular Events in Antigen Processing Antigen processing is a vital step in the immune system’s ability to recognize and respond to pathogens. It involves the breakdown of proteins into smaller peptides that can interact Read More
Antigen cross-presentation Antigen cross-presentation is a critical immunological process that allows exogenous antigens, typically presented via MHC class II to CD4+ T cells, to be presented on MHC class I molecules for recognition by CD8+ Read More
MHC Assembly and Trafficking The Major Histocompatibility Complex (MHC) is a critical component of the immune system, essential for the recognition of foreign molecules and the subsequent immune response. MHC molecules are categorized into two Read More
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