Intratumoral expression of IL-12 and CD40 ligand (CD154) from plasmids generates antitumor responses that eliminate tumoral T regs Summary Delivering plasmids encoding IL-12 and CD40L (CD154) directly into tumors can effectively trigger antitumor immunity. Read More
Nature Immunology, Published online: 08 July 2025; doi:10.1038/s41590-025-02204-9 Effector CD4⁺ T cells restore antiviral CD8⁺ T cell function in the liver by licensing Kupffer cells via CD40–CD40L interactions. This triggers IL-27 Read More
CD2 augmentation enhances CAR-T-cell efficacy via immunological synapse remodeling and T-cell exhaustion mitigation Summary Augmenting CAR-T cells with CD2 enhances their anti-tumor efficacy by improving the immunological synapse. This involves restructuring the synapse architecture for Read More
Metabolic reprogramming via FOXP3 engineering: A Novel strategy to enhance CAR-T cell efficacy in solid tumors Summary Engineering CAR-T cells with the transcription factor FOXP3 can reprogram their metabolism to improve effectiveness against solid tumors. Read More
Nature Immunology, Published online: 30 June 2025; doi:10.1038/s41590-025-02213-8 FOXP3 dependence Summary A new study published in Nature Immunology reveals a crucial dependency on the transcription factor FOXP3 for the sustained suppressive function of Read More
Nature Immunology, Published online: 30 June 2025; doi:10.1038/s41590-025-02216-5 Neurons protect against fibrosis Summary New research published in Nature Immunology reveals a surprising role for neurons in preventing fibrosis. The study demonstrates that neurons, Read More
Nature Immunology, Published online: 30 June 2025; doi:10.1038/s41590-025-02214-7 Train your histones Summary A newly published Nature Immunology article highlights the potential for “training” histones, proteins around which DNA is wrapped, to influence immune Read More
Nature Immunology, Published online: 30 June 2025; doi:10.1038/s41590-025-02215-6 Y do T cells fail Summary A new study published in Nature Immunology (June 30, 2025) investigates the mechanisms behind T cell exhaustion. The research delves into Read More
Nature Immunology, Published online: 30 June 2025; doi:10.1038/s41590-025-02222-7 As interest in tissue-resident immunity, mucosal vaccines and host–microbiota interactions increases, barrier immunology stands at the forefront of immune defense. Summary Barrier immunology is Read More
Nature Immunology, Published online: 30 June 2025; doi:10.1038/s41590-025-02199-3 Here the authors show that CD4+ effector T cells prevent or reverse CD8+ T cell dysfunction by licensing Kupffer cells to trigger IL-27 production, defining Read More
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