Nature Reviews Immunology, Published online: 27 June 2025; doi:10.1038/s41577-025-01187-w

The vasculature that forms in tumours and supports tumour growth is abnormal and limits T cell entry into tumours. Here, the authors review how the tumour vasculature acts as a barrier to effective antitumour immunity and the therapeutic strategies to overcome this.



Summary

Tumor vasculature, critical for tumor growth, presents a significant obstacle to effective anti-tumor immunity by physically hindering T cell infiltration. This review in Nature Reviews Immunology (June 2025) explores how this abnormal tumor vasculature acts as a barrier. The authors discuss the mechanisms behind this impediment and highlight current therapeutic strategies aimed at normalizing the tumor vasculature to facilitate enhanced T cell entry and ultimately improve anti-tumor immune responses. Overcoming this vascular barrier is crucial for optimizing immunotherapy effectiveness.

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