Targeting mTORC2 in lung squamous cell carcinoma improves anti-tumor immunity through the PSGL-1-VISTA axis Summary Targeting mTORC2 in lung squamous cell carcinoma (LUSC) enhances anti-tumor immunity by modulating the PSGL-1-VISTA pathway. Specifically, mTORC2 Read More
Science, Volume 389, Issue 6755, Page 38-38, July 2025. Summary Without knowing the specific content of that particular issue and page of Science, I can only provide a general summary. This entry likely represents an editorial or short “Read More
Orchestrating intratumoral DC-T cell immunity for enhanced tumor control via radiotherapy-activated TLR7/8 prodrugs in mice Summary Researchers developed a novel approach combining radiotherapy (RT) with TLR7/8 agonist prodrugs activated by RT within tumors in mice. Read More
Human cancer-targeted immunity via transgenic hematopoietic stem cell progeny Summary Researchers have developed a novel approach to target cancer using modified hematopoietic stem cells (HSCs). They engineer HSCs to express a tumor-specific T cell receptor (Read More
Researchers have discovered that SARS-CoV-2, the virus that causes COVID-19, may be changing crucial white blood cells called neutrophils … Summary Scientists have found that SARS-CoV-2 can alter neutrophils, a type of white blood cell vital Read More
Engineering STING Nanoadjuvants for spatiotemporally-tailored innate immunity stimulation and cancer vaccination therapy Summary Engineering STING-activating nanoadjuvants offers a promising avenue for enhancing cancer immunotherapy by precisely controlling the location and timing of immune stimulation. These Read More
Heard immunity in CAR T cells Summary “Herd immunity” in CAR T-cell therapy refers to the potential for CAR T-cells from one patient to indirectly protect other patients from the same cancer, even if those Read More
Mathematical mechanistic model representing the cancer immunity cycle under radiation effects Summary This content focuses on a mathematical model designed to simulate the intricate interplay between cancer cells and the immune system, specifically considering the Read More
Nature Reviews Immunology, Published online: 27 June 2025; doi:10.1038/s41577-025-01187-w The vasculature that forms in tumours and supports tumour growth is abnormal and limits T cell entry into tumours. Here, the authors review how Read More
Nature Reviews Immunology, Published online: 13 June 2025; doi:10.1038/s41577-025-01192-z T cells have an essential role in immune responses to Mycobacterium tuberculosis, but the mechanisms by which they may provide protective immunity remain poorly Read More
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