PD-1 receptor deficiency enhances CD30+ Treg cell function in melanoma



Summary

Studies have shown that deficiency in the PD-1 receptor can improve the efficacy of CD30+ Treg cells in melanoma. The absence of PD-1 signaling appears to boost the suppressive function of these regulatory T cells within the tumor microenvironment. Specifically, PD-1 deficient CD30+ Tregs exhibit enhanced expression of inhibitory molecules and improved suppression of effector T cell proliferation. This augmented suppressive activity contributes to immune evasion and tumor progression. Targeting this pathway may offer new strategies to modulate Treg function in melanoma and improve anti-tumor immunity.

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