SARDH in the 1-C metabolism sculpts the T-cell fate and serves as a potential cancer therapeutic target



Summary

SARAH (Sarcosine Dehydrogenase) plays a crucial role in 1-carbon (1-C) metabolism, a pathway vital for cell growth and proliferation. Recent research highlights SARDH’s influence on T-cell differentiation and function. By modulating 1-C metabolism, SARDH impacts T-cell fate, affecting their ability to effectively fight cancer. This discovery suggests that targeting SARDH could offer a novel therapeutic strategy for cancer treatment. Manipulating SARDH activity may potentially reprogram T-cells to enhance their anti-tumor response, representing a promising avenue for developing new cancer immunotherapies.

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