Challenges and perspectives of CAR-T cell therapy in solid tumours: insights from gastric cancer Summary CAR-T cell therapy, while effective in hematological malignancies, faces significant challenges in solid tumors like gastric cancer. These hurdles include Read More
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Education, Research & Positions
Efficacy and safety of immunosuppressive therapy versus cyclosporine combined with
Efficacy and safety of immunosuppressive therapy versus cyclosporine combined with avatrombopag in older adults with severe aplastic anemia: a multicenter prospective study Summary A multicenter prospective study investigated the efficacy and safety of immunosuppressive therapy (Read More
Education, Research & Positions
A new first-line option for advanced-stage anal squamous cell carcinoma
A new first-line option for advanced-stage anal squamous cell carcinoma Summary A novel drug combination of chemotherapy (carboplatin and paclitaxel) plus the immunotherapy drug pembrolizumab has emerged as a promising new first-line treatment for advanced-stage Read More
Education, Research & Positions
Bioengineered immunocompetent preclinical trial-on-chip tool enables screening of CAR T
Bioengineered immunocompetent preclinical trial-on-chip tool enables screening of CAR T cell therapy for leukaemia Summary Researchers have developed a bioengineered “trial-on-chip” system that mimics the human immune system to test CAR T-cell therapy effectiveness against Read More
Education, Research & Positions
CD2 augmentation enhances CAR-T-cell efficacy via immunological synapse remodeling and
CD2 augmentation enhances CAR-T-cell efficacy via immunological synapse remodeling and T-cell exhaustion mitigation Summary Augmenting CAR-T cells with CD2 enhances their anti-tumor efficacy by improving the immunological synapse. This involves restructuring the synapse architecture for Read More
Education, Research & Positions
Perioperative pembrolizumab demonstrates clinical benefit in locally advanced HNSCC
Perioperative pembrolizumab demonstrates clinical benefit in locally advanced HNSCC Summary Perioperative pembrolizumab, combining neoadjuvant and adjuvant immunotherapy around surgery, shows promising clinical benefit in patients with locally advanced head and neck squamous cell carcinoma (HNSCC). Read More
Education, Research & Positions
The European Conference on Infections in Leukaemia (ECIL-10) guidelines for
The European Conference on Infections in Leukaemia (ECIL-10) guidelines for COVID-19 should take convalescent plasma into proper consideration Summary The upcoming ECIL-10 guidelines for COVID-19 management in leukemia patients should thoroughly evaluate the potential benefits Read More
Education, Research & Positions
Impaired autophagy by cepharanthine induces immunogenic cell death and enhances
Impaired autophagy by cepharanthine induces immunogenic cell death and enhances anti-PD-1 response in MSS-type colorectal cancer Summary Cepharanthine, a drug known to impair autophagy, shows promise in enhancing anti-PD-1 immunotherapy for MSS-type colorectal cancer (CRC), Read More
Education, Research & Positions
Is immune effector cell-associated enterocolitis a CAR T-cell lymphoproliferative disorder?
Is immune effector cell-associated enterocolitis a CAR T-cell lymphoproliferative disorder? Summary Immune effector cell-associated enterocolitis (IEC-associated enterocolitis) can manifest after CAR T-cell therapy, presenting with gastrointestinal inflammation. While resembling graft-versus-host disease (GVHD), it’s often Read More
Education, Research & Positions
CAR-T cell therapy for cancer: current challenges and future directions
CAR-T cell therapy for cancer: current challenges and future directions Summary CAR-T cell therapy has revolutionized cancer treatment, particularly for hematologic malignancies, by engineering a patient’s immune cells to target and destroy cancer cells. Read More
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