Challenges and perspectives of CAR-T cell therapy in solid tumours: insights from gastric cancer



Summary

CAR-T cell therapy, while effective in hematological malignancies, faces significant challenges in solid tumors like gastric cancer. These hurdles include limited T-cell infiltration, immunosuppressive tumor microenvironment (TME) hindering CAR-T activity, and a lack of specific, safe target antigens leading to off-target toxicities. Researchers are exploring strategies to overcome these, such as engineering CAR-T cells for enhanced penetration and resistance to the TME, identifying novel and safer targets, and combining CAR-T therapy with other modalities like chemotherapy or checkpoint inhibitors. Overcoming these challenges is crucial to realizing the potential of CAR-T therapy in treating solid tumors.

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