Aging alters the response to CAR T cell therapy



Summary

Aging significantly impacts the effectiveness of CAR T-cell therapy. Older patients often exhibit poorer responses and increased toxicity compared to younger individuals. This is due to age-related changes in the immune system, including decreased T-cell function and increased presence of senescent T cells. These changes impair CAR T-cell expansion, persistence, and tumor-killing capacity. Furthermore, age-associated comorbidities and diminished organ function exacerbate therapy-related toxicities. Research focuses on strategies to overcome these age-related limitations and optimize CAR T-cell therapy for older adults, potentially involving modified CAR T-cell designs or conditioning regimens.

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