Cooperative role of MDSCs and Tregs in alum-induced alloimmune tolerance in corneal transplantation



Summary

Alum, a common vaccine adjuvant, can induce alloimmune tolerance in corneal transplantation by fostering a collaborative relationship between myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs). Alum administration promotes the expansion of MDSCs, which suppress the recipient’s immune response to the donor cornea. Simultaneously, alum enhances the generation and function of Tregs, further dampening the alloimmune reaction. Specifically, MDSCs contribute to Treg induction and stabilization, creating a synergistic effect that leads to long-term corneal graft survival. This highlights the potential of alum-based therapies for promoting tolerance in corneal transplantation by manipulating MDSC and Treg responses.

Read more…

Credits: Source

This post is part of “Science/Immunology News”, Follow for more…!!!