Nature Immunology, Published online: 16 September 2025; doi:10.1038/s41590-025-02281-w

Here Iliev et al. review the interactions between the microbiota and the mucosal immune system from infancy to adulthood, highlighting the impact on health and disease.



Summary

Iliev et al.’s Nature Immunology review, published online on September 16, 2025, explores the complex interplay between the microbiota and the mucosal immune system across the human lifespan. The review focuses on how this interaction evolves from infancy to adulthood and emphasizes its profound consequences for both health maintenance and disease development. By examining this dynamic relationship, Iliev et al. aim to provide a comprehensive understanding of the microbiota’s crucial role in shaping mucosal immunity and its downstream effects on overall wellbeing.

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