Simultaneous STING and lymphotoxin-β receptor activation induces B cell responses in tertiary lymphoid structures to potentiate antitumor immunity



Summary

Activating both the STING and lymphotoxin-β receptor (LTβR) pathways concurrently enhances B cell-mediated antitumor immunity. This simultaneous activation promotes the formation of tertiary lymphoid structures (TLS) within the tumor microenvironment. These TLS act as hubs for immune cell interaction and activation, specifically boosting B cell responses. By stimulating B cells within these TLS, the dual activation strategy strengthens the overall immune attack against the tumor, leading to improved antitumor effects. This approach suggests a promising strategy for cancer immunotherapy by leveraging the synergistic effects of STING and LTβR signaling to recruit and activate B cells within the tumor.

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