Nature Immunology, Published online: 12 August 2025; doi:10.1038/s41590-025-02246-z

A complex of the NF-κB family member p52 and the transcription factor ETS1 is required for B cell germinal center responses to T cell-dependent immunization and for IgE-dependent allergic responses.



Summary

A study published in Nature Immunology reveals the critical role of a protein complex formed by p52 (a member of the NF-κB family) and the transcription factor ETS1 in B cell function. This complex is essential for germinal center formation in B cells following T cell-dependent immunization, a key process for generating high-affinity antibodies. Furthermore, the research demonstrates the importance of this p52-ETS1 complex in driving IgE-dependent allergic responses, highlighting its potential as a therapeutic target for allergic diseases and in modulating B cell immunity.

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