TCF19 drives a broad transcriptional program that potentiates optimal innate and adaptive functions of antiviral NK cells – New Study
Nature Immunology, Published online: 08 August 2025; doi:10.1038/s41590-025-02238-z
Sun and colleagues report that the transcription factor TCF19 regulates calcium signaling and cell cycling progression in NK cells and is required for innate and adaptive NK cell responses to viral infection.
Summary
Sun et al.’s research in Nature Immunology (August 8, 2025) identifies the transcription factor TCF19 as a key regulator of natural killer (NK) cell function. Their study reveals that TCF19 controls calcium signaling and cell cycle progression within NK cells. Critically, TCF19 is shown to be essential for both innate and adaptive NK cell responses during viral infections. This discovery highlights TCF19 as a potential therapeutic target for modulating NK cell activity in the context of viral immunity.
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