Nature Immunology, Published online: 28 July 2025; doi:10.1038/s41590-025-02225-4

Cui et al. discuss new molecular and cellular insights underlying the pathogenesis of rare human diseases that arise from genetic inborn errors of immunity.



Summary

Cui et al. in Nature Immunology review the latest research into the pathogenesis of rare human diseases caused by genetic inborn errors of immunity (IEI). The article focuses on unraveling the complex molecular and cellular mechanisms driving these conditions. By exploring these underlying pathways, the authors aim to improve our understanding of the dysfunctional immune system in IEIs. This knowledge is crucial for developing more targeted and effective therapeutic strategies for individuals affected by these rare and often severe immune disorders.

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