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Train your histones


Nature Immunology, Published online: 30 June 2025; doi:10.1038/s41590-025-02214-7

Train your histones



Summary

A newly published Nature Immunology article highlights the potential for “training” histones, proteins around which DNA is wrapped, to influence immune responses. The research, published online on June 30, 2025, suggests manipulating histone modifications can alter immune cell behavior. This could have significant implications for developing novel immunotherapies, potentially enhancing beneficial immune responses or suppressing harmful ones in autoimmune diseases. The study, accessible via DOI 10.1038/s41590-025-02214-7, opens avenues for further exploring epigenetic control of immunity by directly targeting histone modifications.

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