Nature Immunology, Published online: 16 July 2025; doi:10.1038/s41590-025-02210-x

Feuerer and colleagues use multiomic analyses to identify DNA methylation, chromatin accessibility and gene expression programs that govern the tissue adaptation of human skin Treg cells.



Summary

Feuerer and colleagues published in Nature Immunology on July 16, 2025, using multiomic analyses to uncover the mechanisms behind human skin Treg cell adaptation. The study identifies specific DNA methylation patterns, chromatin accessibility landscapes, and gene expression programs that orchestrate how these regulatory T cells specialize to function within the skin microenvironment. This research sheds light on the epigenetic and transcriptional regulation essential for tissue-specific Treg cell identity and function, offering potential insights for future therapies targeting skin-related immune disorders.

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