Nature Immunology, Published online: 22 July 2025; doi:10.1038/s41590-025-02203-w

In this Resource paper, the authors use MIBI spatial proteomics to map microglial cell states in brains from cognitively normal humans and those with Alzheimer’s disease.



Summary

This Nature Immunology paper employs multiplexed ion beam imaging (MIBI) spatial proteomics to analyze microglial cell states in human brains. Researchers compared brain tissue from cognitively normal individuals and those diagnosed with Alzheimer’s disease. The study aims to characterize the diverse microglial phenotypes and their spatial distribution in both healthy and diseased brains, potentially revealing novel insights into the role of microglia in Alzheimer’s pathogenesis and identifying new therapeutic targets. The authors focus on leveraging spatial context to understand microglial function in the complex brain environment.

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