Nature Immunology, Published online: 24 June 2025; doi:10.1038/s41590-025-02198-4

McGavern and colleagues identified a CD8+ T cell population that expresses GZMK in ʽtau-richʼ brains, where it may play a protective role against neurodegeneration.



Summary

McGavern et al. report a novel finding in Nature Immunology: a specific population of CD8+ T cells expressing the enzyme Granzyme K (GZMK) is present in brains characterized by high levels of tau protein. This is significant because tau accumulation is a hallmark of neurodegenerative diseases. The presence of GZMK-expressing CD8+ T cells suggests a potential protective role against neurodegeneration. This discovery opens new avenues for research exploring immune-mediated mechanisms in neurodegenerative diseases and potentially new therapeutic strategies.

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