Nature Immunology, Published online: 30 June 2025; doi:10.1038/s41590-025-02191-x

Tumor-associated macrophages are pivotal in control over solid tumors. Here the authors show that these macrophages express chemosensors that detect lipid variants in the tumor microenvironment that can regulate the function of these cells.



Summary

Tumor-associated macrophages (TAMs) play a critical role in influencing the behavior of solid tumors. A new study published in Nature Immunology highlights that these macrophages possess chemosensors capable of detecting specific lipid variants within the tumor microenvironment. This detection mechanism is significant because these lipid signals can directly modulate the function of TAMs. These findings suggest potential therapeutic targets by manipulating the lipid signals or chemosensors on TAMs to alter their behavior and ultimately impact tumor progression.

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