Nature Immunology, Published online: 19 June 2025; doi:10.1038/s41590-025-02184-w

The liver portal area has emerged as an important region controlling liver homeostasis and diseases. Tissue macrophages in this region exert immune homeostatic function by capturing antigens, protecting sympathetic nerves and limiting neutrophil recruitment upon inflammation.



Summary

A Nature Immunology article published in 2025 highlights the critical role of the liver portal area in maintaining liver health and managing disease. Resident macrophages within this zone play a vital immune-regulatory function. These macrophages capture antigens, protecting sympathetic nerves and limiting excessive neutrophil recruitment during inflammation. Their actions contribute significantly to overall liver homeostasis, underscoring the importance of the portal area in understanding and treating liver-related conditions.

Read more…

This post is part of “Science/Immunology News”, Follow for more…!!!