Nature Reviews Immunology, Published online: 14 August 2025; doi:10.1038/s41577-025-01211-z

Tumour-associated blood vessels are abnormal in structure and function, and this can limit immune cell infiltration into tumours and contribute to the immunosuppressive tumour microenvironment. This Review highlights how tumour angiogenesis impacts antitumour immunity and explains why combining anti-angiogenic strategies with immunotherapies could improve clinical outcomes for patients with cancer.



Summary

This review in Nature Reviews Immunology (Aug 2025) focuses on the connection between tumor angiogenesis and anti-tumor immunity. Tumors develop abnormal blood vessels that hinder immune cell infiltration, fostering an immunosuppressive microenvironment. The review explores how tumor angiogenesis directly impairs anti-tumor immune responses. Ultimately, the article suggests that combining therapies targeting tumor blood vessel formation (anti-angiogenics) with immunotherapies holds promise for improving cancer treatment outcomes by overcoming the limitations imposed by abnormal tumor vasculature.

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