Nature Reviews Immunology, Published online: 16 June 2025; doi:10.1038/s41577-025-01193-y

Iron is crucial for cellular metabolism, but its availability varies greatly within and between individuals and populations. This Review highlights how iron regulates innate and adaptive cellular and humoral responses affecting protection against infections, tumours and autoimmunity.



Summary

Iron’s fluctuating availability profoundly impacts immunity. This review in Nature Reviews Immunology explores how iron regulates innate and adaptive immune responses, influencing protection against infections, tumors, and autoimmune diseases. The review details how iron regulates cellular and humoral responses, providing critical insight into the complex relationship between iron metabolism and immune function. Understanding these interactions is vital for developing targeted therapies to modulate immunity in various disease states.

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