Nature Reviews Immunology, Published online: 18 June 2025; doi:10.1038/s41577-025-01191-0

During pregnancy, innate immune mechanisms at the maternal–fetal interface are important for protecting the developing fetus from pathogens. However, excessive immune activation can be harmful to the fetus, and these pathways must be properly regulated. Here, the authors discuss the growing understanding of the unique innate immune pathways that operate in the maternal and fetal compartments of the placenta.



Summary

Nature Reviews Immunology highlights the critical role of innate immunity at the maternal-fetal interface during pregnancy. While essential for defending the fetus against pathogens, overactive immune responses can endanger fetal development, necessitating precise regulation. The article focuses on the expanding knowledge of distinct innate immune pathways active in both the maternal and fetal portions of the placenta. Understanding these unique mechanisms is key to comprehending the delicate balance required for a healthy pregnancy.

This post is part of “Immunology News”, Follow for more…!!!

Click on Source link for more details