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Food allergy: begin at the skin, end at the mast cell?


Nature Reviews Immunology, Published online: 26 June 2025; doi:10.1038/s41577-025-01185-y

In this Review the authors explain how different routes of exposure to food antigens can contribute to the development of food allergies. They discuss how allergic sensitization occurs against food antigens and focus on how IgE and mast cells ultimately drive the allergic pathology.



Summary

A recent Nature Reviews Immunology article explores the mechanisms behind food allergy development, focusing on how different exposure routes to food antigens contribute to sensitization. The review highlights the process by which individuals become allergic, emphasizing the role of IgE antibodies and mast cells in driving the characteristic allergic reactions and pathology associated with food allergies. Understanding these pathways is crucial for developing effective prevention and treatment strategies.

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