Multi-omics analysis identifies an M-MDSC-like immunosuppressive phenotype in lineage-switched AML with KMT2A rearrangement



Summary

A multi-omics study reveals that acute myeloid leukemia (AML) with KMT2A rearrangement, following lineage switch, exhibits an immunosuppressive phenotype resembling myeloid-derived suppressor cells (M-MDSCs). This analysis combines genomics, transcriptomics, proteomics, and metabolomics to characterize the molecular landscape of these cells. The findings suggest that lineage-switched AML cells acquire M-MDSC-like features, potentially contributing to immune evasion and therapeutic resistance. Understanding this mechanism is crucial for developing targeted therapies to overcome immunosuppression and improve treatment outcomes in this aggressive AML subtype.

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