Partitioned Hexose Influx Promotes B Cell to PC Transition See article p. 43Cellular Immunity Limits T Cell Memory Formation After LAIV See article p. 107



Summary

This week’s issue highlights research on immune responses. One study (p. 43) reveals how partitioned hexose influx, a specific sugar metabolism pathway, facilitates the transition of B cells into antibody-producing plasma cells (PCs). This suggests a crucial role for cellular metabolism in B cell differentiation and humoral immunity. Another article (p. 107) explores the limitations of live attenuated influenza vaccine (LAIV) in generating long-lasting T cell memory. The research indicates cellular immunity, specifically certain immune cell interactions, restrict the formation of robust T cell memory after LAIV vaccination, potentially impacting long-term protection.

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