This Pillars of Immunology article is a commentary on “Cutting Edge: CATERPILLER: A large family of mammalian genes containing CARD, pyrin, nucleotide-binding, and leucine-rich repeat domains,” a pivotal article written by J. A. Harton, M. W. Linhoff, J. Zhang, and J. P.-Y. Ting,” and published in The Journal of Immunology, in 2002. https://doi.org/10.4049/jimmunol.169.8.4088.



Summary

This Pillars of Immunology commentary reflects on Harton et al.’s 2002 article, "Cutting Edge: CATERPILLER…", published in The Journal of Immunology. The original research introduced the CATERPILLER (later known as NLR) gene family, characterized by CARD, pyrin, nucleotide-binding, and leucine-rich repeat domains. This discovery was significant as it identified a large family of mammalian genes critical for innate immunity. These proteins play roles in inflammasome activation and pathogen recognition, marking a fundamental step in understanding immune responses.

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