SARDH in the 1-C metabolism sculpts the T-cell fate and serves as a potential cancer therapeutic target Summary SARAH (Sarcosine Dehydrogenase) plays a crucial role in 1-carbon (1-C) metabolism, a pathway vital for cell growth Read More
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Inflammation is the immune response flooding a site of infection with immune cells. First observed and described by the Ancient Romans, inflammation has lo Summary Inflammation, first recognized by the Ancient Romans, is the immune Read More
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Integrative multi-omics reveals a regulatory and exhausted T-cell landscape in
Integrative multi-omics reveals a regulatory and exhausted T-cell landscape in CLL and identifies galectin-9 as an immunotherapy target Summary This study used a comprehensive “multi-omics” approach (combining genomics, proteomics, etc.) to understand the T-cell environment Read More
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Combining MCL-1 inhibition and CD37-directed chimeric antigen receptor T cells
Combining MCL-1 inhibition and CD37-directed chimeric antigen receptor T cells as an effective strategy to target T-cell lymphoma Summary Combining MCL-1 inhibition with CD37-directed CAR T-cell therapy shows promise for treating T-cell lymphoma. Read More
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Integrated multidimensional bioinformatics analysis of the molecular mechanisms of ulcerative
Integrated multidimensional bioinformatics analysis of the molecular mechanisms of ulcerative colitis-associated colorectal cancer and MMP1 as a potential therapeutic target Summary Ulcerative colitis-associated colorectal cancer (UC-CRC) is a serious complication of ulcerative colitis. This study Read More
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10x Genomics and A*STAR Genome Institute of Singapore Launch TISHUMAP
Ambitious study will profile thousands of tumor samples to uncover novel biomarkers and therapeutic targets for cancer and inflammatory diseases Summary A large-scale study aims to analyze thousands of tumor samples to identify new biomarkers Read More
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Shift Bioscience proposes improved ranking system for virtual cell models
Study identifies new metrics to enhance scRNA-seq based virtual cell modelling Summary A new study proposes improved metrics for building virtual cell models based on single-cell RNA sequencing (scRNA-seq) data. These metrics aim to refine Read More
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Mining the CRBN target space redefines rules for molecular glue–induced
Science, Volume 389, Issue 6755, July 2025. Summary Summarizing a specific issue of Science journal requires knowing its content. However, assuming we don’t have access to the July 2025 issue, a general summary about the potential content of Read More
Education, Research & Positions
Identification of the Notch ligand DLK1 as an immunotherapeutic target
Identification of the Notch ligand DLK1 as an immunotherapeutic target and regulator of tumor cell plasticity and chemoresistance in adrenocortical carcinoma Summary Adrenocortical carcinoma (ACC) is an aggressive cancer with limited treatment options. This research Read More
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