Nature Immunology, Published online: 19 September 2025; doi:10.1038/s41590-025-02283-8 Here the authors show how the DNA-sensing cGAS–STING pathway activates NF-κB and inflammatory gene expression with delayed kinetics via post-Golgi endolysosomal signaling. Summary Read More
Simultaneous STING and lymphotoxin-β receptor activation induces B cell responses in tertiary lymphoid structures to potentiate antitumor immunity Summary Activating both the STING and lymphotoxin-β receptor (LTβR) pathways concurrently enhances B cell-mediated antitumor immunity. Read More
Engineering STING Nanoadjuvants for spatiotemporally-tailored innate immunity stimulation and cancer vaccination therapy Summary Engineering STING-activating nanoadjuvants offers a promising avenue for enhancing cancer immunotherapy by precisely controlling the location and timing of immune stimulation. These Read More
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