The liver metabolizes dietary galactose to fuel antitumour T cell immunity Summary Dietary galactose, often overlooked, plays a crucial role in fueling anti-tumor T cell responses, particularly when metabolized in the liver. The liver’s Read More
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Education, Research & Positions
Profiling with senescence-associated secretory phenotype score identifies GDC-0879 as a
Profiling with senescence-associated secretory phenotype score identifies GDC-0879 as a small molecule sensitizing glioblastoma to anti-PD1 Summary Glioblastoma (GBM) is a deadly brain cancer with limited treatment options, and immunotherapy’s effectiveness is often hindered. Read More
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ULBP2 CAR-T cells enhance gastric cancer immunotherapy by inhibiting CAF
ULBP2 CAR-T cells enhance gastric cancer immunotherapy by inhibiting CAF activation Summary ULBP2 CAR-T cells show promise in improving gastric cancer immunotherapy by targeting and killing tumor cells and simultaneously disrupting the tumor microenvironment. The Read More
Nanotechnology for immuno-oncology Summary Nanotechnology offers promising solutions for immuno-oncology, enhancing cancer immunotherapy’s effectiveness. Nanoparticles can improve drug delivery to tumors and immune cells, overcoming limitations of traditional methods like poor solubility and systemic Read More
Engineering B cells to treat and study human disease Summary Engineering B cells, the antibody-producing cells of the immune system, offers powerful tools for both treating and studying human diseases. Genetically modified B cells can Read More
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OH2 oncolytic virus inhibits non-small-cell lung cancer metastasis via β-catenin
OH2 oncolytic virus inhibits non-small-cell lung cancer metastasis via β-catenin pathway suppression Summary Oncolytic virus OH2 effectively inhibits non-small-cell lung cancer (NSCLC) metastasis. Researchers demonstrated that OH2 suppresses the Wnt/β-catenin signaling pathway, a key Read More
Manufacturing of CRISPR-edited primary mouse CAR T cells for cancer immunotherapy Summary CRISPR-Cas9 technology can enhance CAR T-cell immunotherapy by improving T-cell function and targeting specificity. This study focuses on a streamlined manufacturing process for Read More
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Combination of pembrolizumab and radiotherapy induces systemic antitumor immune responses
Combination of pembrolizumab and radiotherapy induces systemic antitumor immune responses in immunologically cold non-small cell lung cancer Summary A study demonstrates that combining pembrolizumab, an immunotherapy drug, with radiotherapy can trigger systemic anti-tumor immune responses Read More
Education, Research & Positions
MARCO expression on myeloid-derived suppressor cells is essential for their
MARCO expression on myeloid-derived suppressor cells is essential for their differentiation and immunosuppression Summary Myeloid-derived suppressor cells (MDSCs) require MARCO expression to properly differentiate and exert their immunosuppressive functions. MARCO, a scavenger receptor, plays a Read More
Education, Research & Positions
Metabolic reprogramming in colorectal cancer: a review of aerobic glycolysis
Metabolic reprogramming in colorectal cancer: a review of aerobic glycolysis and its therapeutic implications for targeted treatment strategies Summary Colorectal cancer (CRC) cells exhibit metabolic reprogramming, primarily through aerobic glycolysis, also known as the Warburg Read More
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