Tags :Humanities and Social Sciences
Metabotropic glutamate receptor 4-mediated glutamatfergic signaling reshapes the tumor microenvironment by regulating dendritic cell maturation Summary Metabotropic glutamate receptor 4 (mGluR4) signaling in dendritic cells (DCs) significantly alters the tumor microenvironment. Activation of mGluR4, a glutamate Read More
TRPV1 inhibition sensitizes tumors to PD-1 blockade by reversing resistance to CTL-mediated killing Summary TRPV1 inhibition can enhance the effectiveness of PD-1 blockade immunotherapy in treating tumors. Tumors can develop resistance to cytotoxic T lymphocyte (Read More
Mice with a diverse human T cell receptor repertoire selected on multiple HLA class I molecules Summary Mice were engineered to express a diverse range of human T cell receptors (TCRs) selected based on their Read More
Caffeine enhances antitumor T-cell activity by suppressing kynurenine pathway in colorectal cancer Summary A new study reveals that caffeine boosts the immune system’s ability to fight colorectal cancer by targeting the kynurenine pathway. Caffeine Read More
Engineering STING Nanoadjuvants for spatiotemporally-tailored innate immunity stimulation and cancer vaccination therapy Summary Engineering STING-activating nanoadjuvants offers a promising avenue for enhancing cancer immunotherapy by precisely controlling the location and timing of immune stimulation. These Read More
