Supercharged NK cells: a unique population of NK cells capable of differentiating stem cells and lysis of MHC class I high differentiated tumors Summary A unique population of natural killer (NK) cells, termed “supercharged NK Read More
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TIGIT in cancer: from mechanism of action to promising immunotherapeutic
TIGIT in cancer: from mechanism of action to promising immunotherapeutic strategies Summary TIGIT (T-cell immunoreceptor with Ig and ITIM domains) is an inhibitory receptor on T and NK cells that dampens anti-tumor immunity. It competes Read More
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Targeting LINC01711 in FAP+ cancer-associated fibroblasts overcomes lactate-mediated immunosuppression and
Targeting LINC01711 in FAP+ cancer-associated fibroblasts overcomes lactate-mediated immunosuppression and enhances anti-PD-1 efficacy in lung adenocarcinoma Summary Targeting LINC01711 in cancer-associated fibroblasts (CAFs) expressing fibroblast activation protein (FAP) shows promise in overcoming immunosuppression in lung Read More
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Profiling with senescence-associated secretory phenotype score identifies GDC-0879 as a
Profiling with senescence-associated secretory phenotype score identifies GDC-0879 as a small molecule sensitizing glioblastoma to anti-PD1 Summary Glioblastoma (GBM) is a deadly brain cancer with limited treatment options, and immunotherapy’s effectiveness is often hindered. Read More
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ULBP2 CAR-T cells enhance gastric cancer immunotherapy by inhibiting CAF
ULBP2 CAR-T cells enhance gastric cancer immunotherapy by inhibiting CAF activation Summary ULBP2 CAR-T cells show promise in improving gastric cancer immunotherapy by targeting and killing tumor cells and simultaneously disrupting the tumor microenvironment. The Read More
Education, Research & Positions
IFNγ augments TKI efficacy by alleviating protein unfolding stress to
IFNγ augments TKI efficacy by alleviating protein unfolding stress to promote GSDME-mediated pyroptosis in hepatocellular carcinoma Summary Interferon-gamma (IFNγ) enhances the effectiveness of tyrosine kinase inhibitors (TKIs) in treating hepatocellular carcinoma (HCC) by mitigating protein Read More
Cell Culture Protocol Cell culture is a common laboratory technique to grow and maintain cells under controlled conditions. Here is a general protocol: 1. Cell Culture Basics: – Always work in a sterile environment, such Read More
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