Nature Immunology, Published online: 18 August 2025; doi:10.1038/s41590-025-02235-2 The authors show that the m6A reader protein YTHDF2 negatively regulates Th9 cell differentiation and function. Ablation of YTHDF2 promotes antigen-specific Th9 cell and Read More
Tags :antitumor
Our body is made up of millions of cells that coordinate daily function. They are constantly working to maintain activity and keep us healthy. Cells activa Summary Our bodies are intricate systems composed of millions Read More
Cancer dysregulates the complex structure of tissues and internal cellular pathways. As a result, the immune system loses its ability to effectively target Summary Cancer disrupts normal tissue architecture and cellular functions. This disruption weakens Read More
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Sorafenib-treated Th9 cells exhibit superior anti-tumor effect in lung metastasis
Sorafenib-treated Th9 cells exhibit superior anti-tumor effect in lung metastasis Summary Sorafenib, a multi-kinase inhibitor, enhances the anti-tumor activity of Th9 cells (a type of T helper cell) in lung metastasis models. Specifically, sorafenib treatment Read More
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Anti-tumor immunity is boosted by loss of TGFβ-driven tissue residency
Nature Immunology, Published online: 29 July 2025; doi:10.1038/s41590-025-02224-5 Tumor-infiltrating CD8+ T cells acquire HOBIT expression and features of tissue-resident memory cells. This TGFβ-driven process is dispensable for tumor control by immune checkpoint Read More
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Combination of pembrolizumab and radiotherapy induces systemic antitumor immune responses
Combination of pembrolizumab and radiotherapy induces systemic antitumor immune responses in immunologically cold non-small cell lung cancer Summary A study demonstrates that combining pembrolizumab, an immunotherapy drug, with radiotherapy can trigger systemic anti-tumor immune responses Read More
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Oncolytic virus-mediated p53 activation boosts the antitumor immunity of a
Oncolytic virus-mediated p53 activation boosts the antitumor immunity of a p53-transduced dendritic cell vaccine Summary This research explores combining oncolytic viruses and p53-enhanced dendritic cell (DC) vaccines to improve cancer immunotherapy. Specifically, DCs Read More
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Targeting mTORC2 in lung squamous cell carcinoma improves anti-tumor immunity
Targeting mTORC2 in lung squamous cell carcinoma improves anti-tumor immunity through the PSGL-1-VISTA axis Summary Targeting mTORC2 in lung squamous cell carcinoma (LUSC) enhances anti-tumor immunity by modulating the PSGL-1-VISTA pathway. Specifically, mTORC2 Read More
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Intratumoral expression of IL-12 and CD40 ligand (CD154) from plasmids
Intratumoral expression of IL-12 and CD40 ligand (CD154) from plasmids generates antitumor responses that eliminate tumoral T regs Summary Delivering plasmids encoding IL-12 and CD40L (CD154) directly into tumors can effectively trigger antitumor immunity. Read More
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Caffeine enhances antitumor T-cell activity by suppressing kynurenine pathway in
Caffeine enhances antitumor T-cell activity by suppressing kynurenine pathway in colorectal cancer Summary A new study reveals that caffeine boosts the immune system’s ability to fight colorectal cancer by targeting the kynurenine pathway. Caffeine Read More
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