Worms offer a simple yet powerful whole-organism model for studying senescence, mirroring mammalian aging processes and enabling research into age-related diseases and dormant cancer therapies. Researchers triggered a senescent-like state in worms by altering the activity of the transcription factor TFEB. Typically, when worms go through an extended period of fasting and are then reintroduced […]



Summary

Worms provide a valuable whole-organism model to study senescence, mimicking mammalian aging and offering insights into age-related diseases and dormant cancer treatments. Scientists induced a senescent-like state in worms by manipulating the TFEB transcription factor. By disrupting its usual response to extended fasting followed by reintroduction to food, researchers observed characteristics reminiscent of cellular senescence. This model allows for the investigation of mechanisms driving senescence at the organismal level, potentially uncovering novel therapeutic targets for age-related conditions.

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