Scientists have identified a breakdown in cholesterol transport to neurons in Alzheimer’s disease, a defect linked to the high-risk APOE4 variant. Researchers from the Sant Pau Research Institute (IR Sant Pau), the Clinical Biochemistry Service at Hospital de Sant Pau, and the Spanish Biomedical Research Network in Diabetes and Associated Metabolic Diseases (CIBERDEM) have uncovered […]



Summary

Alzheimer’s disease is linked to defective cholesterol transport to neurons, especially in individuals with the APOE4 variant. Researchers at IR Sant Pau, Hospital de Sant Pau, and CIBERDEM discovered this breakdown, suggesting a new target for therapeutic intervention. The study highlights the importance of proper cholesterol delivery for neuronal health and identifies a potential mechanism contributing to Alzheimer’s development. By understanding this cholesterol transport dysfunction, scientists aim to develop strategies to improve neuronal function and potentially slow or prevent the progression of the disease.

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