Cascade amplification of therapeutic payloads for cancer immunotherapy



Summary

“Cascade amplification of therapeutic payloads” in cancer immunotherapy refers to strategies designed to enhance the efficacy of delivered drugs or immunomodulatory agents within the tumor microenvironment. By triggering a series of amplifying events after initial delivery, these methods aim to overcome limitations such as drug resistance, insufficient immune activation, and systemic toxicity.

These amplifying events can involve enzymatic reactions, self-assembly of nanoparticles, or the release of secondary therapeutic agents. The initial trigger activates a cascade that exponentially increases the concentration or activity of the payload specifically within the tumor, leading to a more potent and localized therapeutic effect while minimizing off-target effects. This approach is gaining traction for improving cancer immunotherapy outcomes.

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