Inherited mitochondrial genetics as a predictor of immune checkpoint inhibition efficacy in melanoma



Summary

Inherited mitochondrial DNA (mtDNA) variants influence the effectiveness of immune checkpoint inhibitors (ICIs) in melanoma. Studies reveal a correlation between specific mtDNA haplogroups and ICI response, suggesting that inherited mitochondrial function plays a role in shaping anti-tumor immunity. This influence stems from mtDNA’s impact on cellular metabolism, ROS production, and inflammation, all crucial for effective immune responses. Analyzing a patient’s mtDNA could potentially predict their likelihood of responding to ICIs, enabling personalized treatment strategies and improving outcomes for melanoma patients. Understanding the mechanisms by which mtDNA affects immunity opens avenues for developing novel therapies to enhance ICI efficacy.

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