Spatial and functional diversity of innate lymphoid cells in the human female genital tract may contribute to antiviral responses to HIV – New Study
Nature Immunology, Published online: 22 September 2025; doi:10.1038/s41590-025-02285-6
The authors spatially and functionally map innate lymphoid cells in the human female genital tract at homeostasis, uncovering tissue-specific and subset-specific distribution and functions, and rapid antiviral responses following HIV exposure.
Summary
A new Nature Immunology study published in September 2025 details the spatial distribution and function of innate lymphoid cells (ILCs) in the healthy human female genital tract. Researchers mapped these cells, revealing distinct tissue-specific locations and subset-specific roles. Importantly, the study also demonstrates the rapid antiviral response of these ILCs following exposure to HIV. This research provides valuable insights into the female genital tract’s innate immune landscape and its role in early defense against viral infections like HIV.
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