STING signals to NF-κB from late endolysosomal compartments using IRF3 as an adaptor – New Study
Nature Immunology, Published online: 19 September 2025; doi:10.1038/s41590-025-02283-8
Here the authors show how the DNA-sensing cGAS–STING pathway activates NF-κB and inflammatory gene expression with delayed kinetics via post-Golgi endolysosomal signaling.
Summary
A Nature Immunology article published September 19, 2025, reveals a novel mechanism of the cGAS-STING pathway. The authors demonstrate that DNA sensing via cGAS-STING activates NF-κB and subsequent inflammatory gene expression through a delayed process involving post-Golgi endolysosomal signaling. This finding expands our understanding of the innate immune response to DNA and highlights the importance of endolysosomes in propagating downstream signaling from the cGAS-STING pathway, offering potential new therapeutic targets for inflammatory diseases.
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