Nature Immunology, Published online: 15 September 2025; doi:10.1038/s41590-025-02280-x

Wang and colleagues show that an AI-assisted designed peptide obstructs GSDMD pores and inhibits IL-1β and IL-18 release and pyroptosis.



Summary

A study published in Nature Immunology details how Wang and colleagues utilized artificial intelligence to design a peptide that effectively blocks GSDMD pores. This blockage significantly inhibits the release of the inflammatory cytokines IL-1β and IL-18, ultimately preventing pyroptosis, a form of inflammatory cell death. This AI-designed peptide offers a novel therapeutic approach by directly targeting GSDMD, a key player in inflammatory pathways, providing a potential treatment for conditions driven by excessive inflammation and cell death.

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