LPS structure shapes T<sub>reg</sub> cells – New Study
Nature Immunology, Published online: 29 August 2025; doi:10.1038/s41590-025-02272-x
LPS structure shapes Treg cells
Summary
A 2025 Nature Immunology study reveals that the structure of lipopolysaccharide (LPS), a major component of gram-negative bacteria, significantly influences the development and function of regulatory T cells (Treg cells). These Treg cells are crucial for immune tolerance and preventing autoimmunity. The research demonstrates that specific LPS structures can either promote or inhibit Treg cell differentiation and suppressive activity. This finding suggests that manipulating LPS structure through dietary interventions or targeted therapies could offer novel approaches to modulating the immune system and treating inflammatory and autoimmune diseases. This emphasizes the important link between gut microbiota, LPS composition, and immune regulation.
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