The pre-T cell receptor as a tumor immunotherapy target in T cell leukemia – New Study
Nature Immunology, Published online: 05 September 2025; doi:10.1038/s41590-025-02269-6
The pre-T cell receptor is essential for T cell development. It is also an emerging immunotherapy target.
Summary
The pre-T cell receptor (pre-TCR) is crucial for T cell development, a fundamental process in the immune system. Beyond its role in lymphocyte formation, the pre-TCR is increasingly recognized as a potential target for immunotherapy. This means researchers are exploring ways to manipulate or influence the pre-TCR to treat diseases, likely focusing on enhancing or suppressing T cell activity for therapeutic benefit. Published in Nature Immunology, this research highlights the dual importance of the pre-TCR in both basic T cell biology and innovative immunotherapy strategies.
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