Nature Immunology, Published online: 15 September 2025; doi:10.1038/s41590-025-02268-7

Here the authors spatially map human pediatric low-grade gliomas using imaging mass cytometry, focusing on immunosuppressive myeloid cell populations and their functionality in tumor–immune interactions and tumor progression.



Summary

A study published in Nature Immunology on September 15, 2025, used imaging mass cytometry to spatially map human pediatric low-grade gliomas. The research focused on characterizing immunosuppressive myeloid cell populations within the tumors. By analyzing the spatial relationships and functionality of these myeloid cells, the authors aimed to understand their role in shaping tumor–immune interactions and driving tumor progression. The study offers valuable insights into the immune landscape of these brain tumors and potentially identifies new therapeutic targets.

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