Editorial Expression of Concern: Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR – New Study
Nature Immunology, Published online: 20 August 2025; doi:10.1038/s41590-025-02264-x
Editorial Expression of Concern: Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR
Summary
Nature Immunology has issued an Editorial Expression of Concern regarding a previously published article (doi:10.1038/s41590-025-02264-x). The concern relates to the original paper’s findings that Bcl-6, a protein crucial for germinal center B cell function and linked to lymphoma development, acts by suppressing the DNA-damage sensor ATR through transcriptional repression. The specific nature of the concern prompting this notice isn’t detailed in this brief summary, but it suggests potential issues with the validity or reliability of the published conclusions regarding Bcl-6 and ATR. Readers are advised to consider this expression of concern when interpreting the original paper’s results.
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