Epigenetic imprinting in innate lymphoid cell precursors directs the lineage segregation of innate lymphoid cells – New Study
Nature Immunology, Published online: 18 September 2025; doi:10.1038/s41590-025-02261-0
Wang and colleagues show that specific DNA methylation profiles mark the ILC progenitors (ILCP) that would differentiate into ILC1, ILC2 or ILC3 subsets.
Summary
Wang et al., in a Nature Immunology study, identified unique DNA methylation patterns differentiating ILC progenitor (ILCP) cells destined to become ILC1, ILC2, or ILC3 subsets. This research suggests that epigenetic modifications, specifically DNA methylation, play a crucial role in pre-determining the developmental fate of these innate lymphoid cell subtypes. By characterizing these distinct methylation profiles, the study sheds light on the mechanisms governing ILC differentiation and contributes to a deeper understanding of immune system development and function. These findings could have implications for manipulating ILC responses in disease contexts.
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