Nature Immunology, Published online: 13 August 2025; doi:10.1038/s41590-025-02245-0

Circadian oscillation of gene expression controls gut tissue homeostasis. The transcription factors REV-ERBα and REV-ERBβ, which control the expression of clock genes, are also central to maintaining innate lymphoid cells in a state that facilitates the maintenance of a balanced and healthy intestine.



Summary

A Nature Immunology study (August 13, 2025) reveals that the circadian rhythm, regulated by clock genes, is crucial for maintaining gut tissue homeostasis. The transcription factors REV-ERBα and REV-ERBβ, key regulators of these clock genes, also play a vital role in keeping innate lymphoid cells in a state that promotes a balanced and healthy intestinal environment. This suggests a direct link between the body’s internal clock and gut health through the control of immune cell activity within the intestine.

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