CGRP-related neuropeptide adrenomedullin 2 promotes tissue-protective ILC2 responses and limits intestinal inflammation – New Study
Nature Immunology, Published online: 15 August 2025; doi:10.1038/s41590-025-02243-2
Artis and colleagues show that enteric neurons produce CGRP-related ADM2 to promote intestinal tissue-protective functions in ILC2s.
Summary
A new study in Nature Immunology reveals a novel role for enteric neurons in regulating intestinal immunity. Artis and colleagues discovered that these neurons produce ADM2, a molecule related to CGRP, which directly stimulates ILC2s (group 2 innate lymphoid cells) in the gut. This neuronal-ILC2 interaction promotes tissue-protective functions within the intestinal environment. This finding highlights the intricate interplay between the nervous and immune systems in maintaining intestinal health and offers potential therapeutic targets for inflammatory bowel diseases.
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